Preheat & Prep: Preheat your oven to 425°F (220°C). Line a large baking sheet with parchment paper.
Make the Batter: In a large bowl, whisk together the flour, garlic powder, onion powder, and salt. Slowly whisk in the milk until a smooth, thin batter forms.
Coat the Cauliflower: Add the cauliflower florets to the bowl and toss gently to coat each piece evenly.
First Bake: Arrange the battered cauliflower in a single layer on the prepared baking sheet, ensuring there is space between them. Bake for 20 minutes, flipping the florets halfway through, until the coating is dry and lightly golden.
Make Buffalo Sauce: While the cauliflower is baking, whisk together the buffalo sauce and the melted butter in a large, clean bowl.
Sauce the Cauliflower: Remove the cauliflower from the oven and carefully add it to the bowl with the buffalo sauce. Toss gently until every piece is fully coated.
Second Bake: Pour the sauced cauliflower back onto the baking sheet in a single layer. Return to the oven and bake for another 10-15 minutes, until the sauce is bubbly and the edges of the cauliflower are crispy and slightly caramelized.
Serve: Serve immediately with a side of ranch or blue cheese dressing for dipping and a sprinkle of fresh chives.