Preheat & Prep: Preheat your oven to 425°F (220°C). Line a large baking sheet with parchment paper.
Pat Fish Dry: Thoroughly pat the fish fillets dry on both sides with a paper towel. Season them lightly with a pinch of salt and pepper.
Set Up Breading Station: You will need three shallow dishes.
In the first dish, whisk together the flour, 1/2 tsp paprika, 1/2 tsp garlic powder, 1/2 tsp salt, and 1/4 tsp pepper.
In the second dish, lightly beat the eggs.
In the third dish, combine the Panko breadcrumbs with the remaining 1/2 tsp paprika, 1/2 tsp garlic powder, 1/2 tsp salt, and 1/4 tsp pepper.
Coat the Fish: Working with one fillet at a time, first dredge it in the seasoned flour, shaking off the excess. Next, dip it fully into the egg wash, allowing the excess to drip off. Finally, press the fillet firmly into the Panko mixture, ensuring it is completely coated on all sides.
Arrange and Bake: Place the coated fish fillets on the prepared baking sheet, leaving space between them. Lightly spritz the tops with olive oil spray or drizzle with melted butter.
Bake: Bake for 12-15 minutes, or until the coating is golden brown and crispy, and the fish flakes easily with a fork. There's no need to flip them.
Serve: Serve immediately with fresh lemon wedges and your favorite sides.